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CAS No.: 4800-94-6

羧苄青霉素 Catalog No. CSN16742

Synonyms: Sodium carbenicillin;BRL-2064;Carbenicillin (sodium salt)

Carbenicillin disodium is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of Gram-negative bacteria while displaying low toxicity.

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生物活性

描述Carbenicillin disodium is a beta-lactam penicillin derivative that interference with final stage of bacterial cell wall synthesis. Particulate matter from carbenicillin disodium may not be toxic to human macrophages in vitro for up to six days^[2]. Carbenicillin (and ticarcillin) for the present would seem better reserved for P. aeruginosa infections^[3]. At pH 5, the reduced action of esterase and the increased absorption rate after 3 hr resulted in 50 and 60% absorption of carbenicillin phenyl sodium and carbenicillin indanyl sodium, respectively^[4]. Moreover, if the combination of carbenicillin and gentamicin is used in patients with severe renal failure, the dose of carbenicillin should be reduced to prevent rapid inactivation of gentamicin^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02099240	Osteomyelitis	Early Phase 1	Recruiting	September 2019	United States, Kentucky ... more >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu Sub-Investigator: Forest Arnold, DO Sub-Investigator: Timothy Wiemkwn, PhD Sub-Investigator: Robert Kelley, PhD Sub-Investigator: James Summersgill, PhD Sub-Investigator: Ruth Carrico, PhD Sub-Investigator: Julie Harting, PharmD Sub-Investigator: Paula Peyrani, MD Principal Investigator: David Seligson, MD Sub-Investigator: Craig Roberts, MD Principal Investigator: Julio Ramirez, MD Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.3676 mL
- 11.8381 mL
- 23.6763 mL
- 5 mM
- 0.4735 mL
- 2.3676 mL
- 4.7353 mL
- 10 mM
- 0.2368 mL
- 1.1838 mL
- 2.3676 mL

技术信息

CAS号

4800-94-6

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H16N2Na2O6S

运输

蓝冰

分子量

422.36

别名

Sodium carbenicillin;BRL-2064;Carbenicillin (sodium salt);α-Carboxybenzylpenicillin;CP 15,639-2;NSC 111071;Carbenicillin Disodium;Carbenicillin sodium;Carbecin;羧苄青霉素二钠

溶解度

DMSO	5.0 mg/mL (11.8 mM)
Ethanol	Insoluble

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